What action is taken when crossmatch results indicate incompatibility?

When crossmatch results indicate incompatibility, the appropriate action is to use different donors. This is because an incompatibility in crossmatching suggests that the recipient's immune system may react adversely to the donor blood due to the presence of different blood group antigens. Therefore, selecting a different donor whose blood is compatible with the recipient is critical to ensure patient safety and avoid potential transfusion reactions.

Utilizing different donors allows for the possibility of finding an alternative blood type that is compatible, which is essential for the successful administration of a blood transfusion. This step is a standard practice in transfusion medicine to prevent any serious complications associated with blood transfusion, such as hemolytic reactions, which can occur if incompatible blood is administered.

Re-testing the samples, while important in some scenarios, is generally not the first response to incompatibility, as the primary concern is to ensure the transfusion is safe by ensuring compatibility with another donor. Administering blood transfusion without confirming compatibility would be hazardous and is not a standard approach. Performing additional serological tests may provide further information, but the immediate action should prioritize finding a compatible donor to ensure patient safety.