What does a sickle cell screen analyze in the blood?

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The sickle cell screen primarily analyzes the types of hemoglobin present in an individual's blood, particularly focusing on the abnormal hemoglobin known as hemoglobin S (HbS), which is responsible for sickle cell disease. High-Pressure Liquid Chromatography (HPLC) is one of the methods used for this analysis. HPLC effectively separates different types of hemoglobin based on their chemical properties, allowing for the identification of HbS and other variants. This method is sensitive and specific, making it a reliable choice for distinguishing normal hemoglobin from the abnormal forms associated with sickle cell disease.

Other methods may be used for sickle cell screening, but HPLC is notable for its precision and effectiveness in quantifying the various hemoglobin types present in the sample, which is crucial for accurate diagnosis and management of sickle cell disease.

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