What is Tamm-Horsfall protein produced by?

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Tamm-Horsfall protein, also known as uromodulin, is predominantly produced by the renal tubules, specifically the thick ascending limb of the loop of Henle in the kidneys. This protein plays a crucial role in urinary function, including the regulation of sodium and potassium levels, as well as potentially influencing the formation of urinary casts and stones.

In the context of renal physiology, Tamm-Horsfall protein is essential for maintaining proper renal homeostasis and contributes to the defense against urinary tract infections by binding to pathogens and preventing their adherence to uroepithelial cells. The unique location of its production in the renal tubules underscores its importance in kidney function and overall urinary health.

The other options, such as liver cells, pituitary gland, and pancreatic cells, are not involved in the production of Tamm-Horsfall protein; thus, they do not contribute to its physiological role in the body.

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