What is the purpose of using CMV negative blood?

Using CMV negative blood is crucial for certain vulnerable populations, including low-birth-weight infants and transplant patients. Cytomegalovirus (CMV) is a common virus that can be transmitted through blood transfusions, and while it may not pose a significant risk to healthy adults, it can have serious consequences for immunocompromised individuals.

For low-birth-weight infants, who have undeveloped immune systems, exposure to CMV can lead to severe infections and complications. Similarly, transplant patients are often on immunosuppressive medications to prevent organ rejection, making them more susceptible to infections, including those caused by CMV. As a precaution, using CMV negative blood helps to minimize the risk of such infections, ensuring a safer transfusion for these high-risk groups.

This practice is part of a broader effort to enhance patient safety in transfusion medicine, specifically tailored to protect those who are more vulnerable due to underlying health conditions or developmental factors.