Which anticoagulant is associated with an antidote of Protamine Sulfate?

Heparin is the anticoagulant associated with the antidote protamine sulfate. Heparin is a rapidly acting anticoagulant that is commonly used in various clinical settings, especially in situations requiring immediate anticoagulation, such as during surgeries or in patients with acute coronary syndromes. When bleeding occurs or there is a need to reverse the effects of heparin, protamine sulfate is administered because it effectively neutralizes heparin's anticoagulant effects.

Protamine sulfate acts by binding to heparin, forming a stable complex that effectively counteracts heparin's action and allows for normal clotting to resume. In contrast, other anticoagulants, such as warfarin (also known as Coumadin), have different mechanisms and antidotes. Vitamin K is the antidote for warfarin, while aspirin, which is not an anticoagulant but an antiplatelet, does not have a specific antidote for reversing its effects. Therefore, the use of protamine sulfate specifically correlates with heparin and not with the other medications listed.