Which condition can cause interference in hemoglobin measurement?

Hyperlipidemia can interfere with hemoglobin measurement primarily due to the presence of excess lipids in the serum, which can affect the optical density readings used in various measurement techniques. When blood samples have high levels of lipids, the turbidity can cause inaccurate measurements of hemoglobin, leading to falsely elevated or decreased readings depending on the specific method used to analyze the blood.

Other conditions mentioned, such as low serum protein, normal bilirubin levels, and low white blood cell counts, typically do not have the same level of interference associated with hemoglobin measurements. Low serum protein might not significantly affect the optical properties of the sample, while normal bilirubin levels are generally not expected to distort the hemoglobin readouts. A low white blood cell count does not impact hemoglobin measurement because it relates primarily to the cell line involved in the immune response rather than red blood cell function or measurement. Thus, hyperlipidemia stands out as the condition most likely to cause significant interference in hemoglobin measurement.