Which enzyme levels are known to correlate with jaundice?

The correlation between enzyme levels and jaundice is particularly significant when considering alkaline phosphatase and gamma-glutamyl transferase (GGT). Jaundice occurs due to elevated levels of bilirubin in the blood, which can arise from various conditions affecting the liver, bile ducts, or hemolysis.

Alkaline phosphatase is an enzyme that is notable for its increase in liver and biliary tract diseases. Elevated levels indicate cholestasis or obstruction in the bile ducts, which can lead to the accumulation of bilirubin in the bloodstream, contributing to jaundice. Similarly, GGT is another enzyme whose levels may rise in conjunction with alkaline phosphatase in conditions where there is liver or biliary involvement. Its elevation helps distinguish between liver disease and bone disease as causes of elevated alkaline phosphatase.

In this context, measuring alkaline phosphatase and GGT together provides a clearer picture of the underlying issues that might be causing jaundice, making them reliable indicators for diagnosis and management of jaundice-related conditions. Therefore, the correlation of these enzyme levels with jaundice is well-established in clinical practice.