Which two transamines are commonly correlated with liver disease?

The two transaminases that are commonly correlated with liver disease are aspartate aminotransferase (AST) and alanine aminotransferase (ALT). These enzymes play a critical role in amino acid metabolism and are found primarily in the liver, with smaller amounts occurring in other tissues such as the heart and muscle.

When liver cells are damaged, AST and ALT are released into the bloodstream, leading to elevated levels that can serve as indicators of liver dysfunction or injury. ALT is particularly specific to liver tissue, making it a key enzyme for assessing hepatic health. In the context of liver diseases such as hepatitis, cirrhosis, or fatty liver disease, clinicians often evaluate the levels of these transaminases to gain insight into the state of liver health.

The other choices listed involve enzymes that are associated with different conditions. Troponin and myoglobin are related to cardiac muscle injury, amylase and lipase are primarily associated with pancreatitis, while GGT and alkaline phosphatase (AP) are more often linked with cholestasis or bile duct obstruction rather than direct liver cell injury. Therefore, AST and ALT are the correct choice for evaluating liver disease.